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KMID : 0043319950180050332
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Archives of Pharmacal Research
1995 Volume.18 No. 5 p.332 ~ p.335
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In vivo Angiogenic Activity of Dichloromethane Extracts of Aloe vera Gel
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Lee Myoung-Jin
Yoon Soo-Hong
Lee Seung-Ki
Chung Myung-Hee
Park Young-In
Sung Chung-Ki
Choi Jae-Sue
Kim Kyu-Won
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Abstract
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The angiogenic activity of Aloe vera (Aloe baradensis), known as a good healing plant, was investigated. We have extracted and fractionated dichloromethane extract (G1M1D1) and methanol soluble fraction of dichloromethane extract (G1M1D1M1) which contain low-molecular weight substances of Aloe vera gel. G1M1D1 and G1D1M1 fractions induced a radially arranged, spoke-sheel-like vasculature in chick embryo chorioallantoic membrane (CAM) assay. The angiogenic activity was dose-dependent and the angiogenic pattern in the CAM assay. The angiogenic activity was dose-dependent and the angiogenic pattern in the CAM assay was very similar to that of phorbol 12-myristate-13-acetate (PMA) used as a positive control. The modified CAM assay, e simple and accurate quantitating method, was used to quntitate the angiogenic activity of G1D1M1 fraction. Application of G1M1D1M1 fraction () resulted in much more intense angiogenesis than in control while slightly less intense angiogenesis than in PMA (100 ng/egg).
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KEYWORD
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Angiogenesis, Chorioallantoic membrane (CAM) assay, Modified CAM assay, Phorbol 12-myristate-13-acetate(PMA)
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